C57BL/6-Pdcd1tm1(PDCD1)Bcgen Cd274tm1(CD274)Bcgen Vsirtm1(VSIR)Bcgen/Bcgen • 131336
| Product name | B-hPD-1/hPD-L1/hVSIR mice |
|---|---|
| Catalog number | 131336 |
| Strain name | C57BL/6-Pdcd1tm1(PDCD1)Bcgen Cd274tm1(CD274)Bcgen Vsirtm1(VSIR)Bcgen/Bcgen |
| Strain background | C57BL/6 |
| NCBI gene ID | 5133,29126,64115 (Human) |
| Aliases | PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; ADMIO4; AIMTBS; B7-H; B7H1; PDL1; PD-L1; ADMIO5; hPD-L1; PDCD1L1; PDCD1LG1; B7H5; GI24; B7-H5; Dies1; PD-1H; SISP1; VISTA; PP2135; C10orf54; DD1alpha |
Strain specific PD-1 and PD-L1 expression analysis in wild-type C57BL/6 mice and homozygous B-hPD-1/hPD-L1/hVSIR mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hPD-1/hPD-L1/hVSIR mice (H/H) after stimulated with anti-CD3ε in vivo. Mouse PD-1 and PD-L1 were detectable in wild-type C57BL/6 mice. Human PD-1 and PD-L1 were exclusively detectable in homozygous B-hPD-1/hPD-L1/hVSIR mice but not in wild-type mice.
Strain specific VSIR expression analysis in wild-type C57BL/6 mice and homozygous B-hPD-1/hPD-L1/hVSIR mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hPD-1/hPD-L1/hVSIR mice (H/H). Mouse VSIR was only detectable in wild-type C57BL/6 mice. Human VSIR was exclusively detectable in homozygous B-hPD-1/hPD-L1/hVSIR mice but not in wild-type mice.
