C57BL/6-Cd122tm2(CD122)Bcgen/Bcgen • 110737
| Product name | B-hIL2RB mice |
|---|---|
| Catalog number | 110737 |
| Strain name | C57BL/6-Cd122tm2(CD122)Bcgen/Bcgen |
| Strain background | C57BL/6 |
| NCBI gene ID | 3560 (Human) |
| Aliases | CD122; IMD63; IL15RB; P70-75 |
Gene targeting strategy for B-hIL2RB mice. The exons 2~8 of mouse Cd122 gene that encodes the extracellular domain were replaced by human CD122 exons 2~8 in B-hIL2RB mice.
Strain specific IL2RB expression analysis in heterozygous B-hIL2RB mice by flow cytometry. Splenocytes were collected from WT mice and heterozygous B-hIL2RB mice (H/+) stimulated with anti-CD3ε in vivo, and analyzed by flow cytometry with species-specific anti-IL2RB antibody. Mouse IL2RB was detectable in WT and heterozygous B-hIL2RB mice. Human IL2RB was exclusively detectable in heterozygous B-hIL2RB mice but not in WT mice.
