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    B-hAPOE2 mice

    C57BL/6JNifdc-Apoetm1(APOE*2)Bcgen/Bcgen • 112562

    B-hAPOE2 mice

    Product nameB-hAPOE2 mice
    Catalog number112562
    Strain nameC57BL/6JNifdc-Apoetm1(APOE*2)Bcgen/Bcgen
    Strain backgroundC57BL/6JNifdc
    NCBI gene ID348 (Human)
    AliasesAD2; LPG; APO-E; ApoE4; LDLCQ5

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    • Phenotypic analysis

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      发表文章

        mRNA expression analysis
        Strain specific analysis of APOE2 mRNA expression in wild-type C57BL/6J mice and B-hAPOE2 mice by RT-PCR. Brain RNA was isolated from wild-type C57BL/6J mice (+/+) and homozygous B-hAPOE2 mice (H/H), then cDNA libraries were synthesized by reverse transcription, followed by PCR with mouse or human APOE primers. Mouse Apoe mRNA was detectable only in wild-type C57BL/6J mice. Human APOE2 mRNA was detectable only in homozygous B-hAPOE2 mice but not in wild-type mice.
        Protein expression analysis

        Strain specific APOE2 expression analysis in homozygous B-hAPOE2 mice by ELISA. Serum was collected from wild-type mice C57BL/6 mice (+/+) and homozygous B-hAPOE2 mice (H/H), and analyzed by ELISA with species-specific APOE ELISA kit (Abcam, ab233623; Abcam, ab215086). Mouse APOE was detectable in wild-type mice. Human APOE2 was exclusively detectable in homozygous B-hAPOE2 mice but not in wild-type mice.

        * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-hAPOE2 mice] (Cat# 112562) was purchased from Biocytogen.